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AID hits the jackpot when missing the target
Activation induced deaminase is the single B cell specific factor mediating class switch recombination and somatic hypermutation. Numerous studies have shown that AID preferentially targets Ig substrates and also attacks non-Ig substrates to create DNA damage that contributes to lymphomagenesis. AID...
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| Publié dans: | Curr Opin Immunol |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4979549/ https://ncbi.nlm.nih.gov/pubmed/26845615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2016.01.008 |
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