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AID targeting is dependent on RNA polymerase II pausing
Activation induced deaminase (AID) is globally targeted to immunoglobulin loci, preferentially focused to switch (S) regions and variable (V) regions, and prone to attack hotspot motifs. Nevertheless, AID deamination is not exclusive to Ig loci and the rules regulating AID targeting remain unclear....
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3630797/ https://ncbi.nlm.nih.gov/pubmed/22784681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.smim.2012.06.001 |
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