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CDK9-dependent RNA polymerase II pausing controls transcription initiation

Gene transcription can be activated by decreasing the duration of RNA polymerase II pausing in the promoter-proximal region, but how this is achieved remains unclear. Here we use a ‘multi-omics’ approach to demonstrate that the duration of polymerase pausing generally limits the productive frequency...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Gressel, Saskia, Schwalb, Björn, Decker, Tim Michael, Qin, Weihua, Leonhardt, Heinrich, Eick, Dirk, Cramer, Patrick
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669633/
https://ncbi.nlm.nih.gov/pubmed/28994650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29736
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