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Defective DNA repair increases susceptibility to senescence through extension of Chk1-mediated G2 checkpoint activation
Susceptibility to senescence caused by defective DNA repair is a major hallmark of progeroid syndrome patients, but molecular mechanisms of how defective DNA repair predisposes to senescence are largely unknown. We demonstrate here that suppression of DNA repair pathways extends the duration of Chk1...
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| Publié dans: | Sci Rep |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4979019/ https://ncbi.nlm.nih.gov/pubmed/27507734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31194 |
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