The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy

CBP-93872 suppresses maintenance of DNA double-stranded break-induced G2 checkpoint, by inhibiting the pathway between ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) activation. To examine the potential use of CBP-93872 for clinical applications, we analyzed the synergistic effe...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Iwata, Tsutomu, Uchino, Tairin, Koyama, Ayako, Johmura, Yoshikazu, Koyama, Kenichi, Saito, Takuya, Ishiguro, Seiji, Arikawa, Takashi, Komatsu, Shunichiro, Miyachi, Masahiko, Sano, Tsuyoshi, Nakanishi, Makoto, Shimada, Midori
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448762/
https://ncbi.nlm.nih.gov/pubmed/28558031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178221
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