Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1

Argininosuccinate synthase 1 (ASS1) is the rate-limiting enzyme for arginine biosynthesis. ASS1 expression is lost in a range of tumor types, including 50% of malignant pleural mesotheliomas. Starving ASS1-deficient cells of arginine with arginine blockers such as ADI-PEG20 can induce selective leth...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Locke, Matthew, Ghazaly, Essam, Freitas, Marta O., Mitsinga, Mikaella, Lattanzio, Laura, Lo Nigro, Cristiana, Nagano, Ai, Wang, Jun, Chelala, Claude, Szlosarek, Peter, Martin, Sarah A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978703/
https://ncbi.nlm.nih.gov/pubmed/27452468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.06.097
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