Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis

OBJECTIVE: We identified significant expression of the matricellular protein, DEL1, in hypertrophic and mature cartilage during development. We hypothesized that this tissue-specific expression indicated a biological role for DEL1 in cartilage biology. METHODS: Del1 KO and WT mice had cartilage thic...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Wang, Zhen, Tran, Misha C., Bhatia, Namrata J., Hsing, Alexander W., Chen, Carol, LaRussa, Marie F., Fattakhov, Ernst, Rashidi, Vania, Jang, Kyu Yun, Choo, Kevin J., Nie, Xingju, Mathy, Jonathan A., Longaker, Michael T., Dauskardt, Reinhold H., Helms, Jill A., Yang, George P.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978450/
https://ncbi.nlm.nih.gov/pubmed/27505251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160684
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