Functional Knockout of the Matrilin-3 Gene Causes Premature Chondrocyte Maturation to Hypertrophy and Increases Bone Mineral Density and Osteoarthritis

Mutations in the gene encoding matrilin-3 (MATN3), a noncollagenous extracellular matrix protein, have been reported in a variety of skeletal diseases, including multiple epiphyseal dysplasia, which is characterized by irregular ossification of the epiphyses and early-onset osteoarthritis, spondylo-...

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Detalhes bibliográficos
Main Authors: van der Weyden, Louise, Wei, Lei, Luo, Junming, Yang, Xu, Birk, David E., Adams, David J., Bradley, Allan, Chen, Qian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698783/
https://ncbi.nlm.nih.gov/pubmed/16877353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.050981
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