Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

Osteoarthritis is a common debilitating joint disorder. Risk factors for osteoarthritis include age, which is associated with thinning of articular cartilage. Here we generate chondrocyte-specific salt-inducible kinase 3 (Sik3) conditional knockout mice that are resistant to osteoarthritis with thic...

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Udgivet i:Nat Commun
Main Authors: Yahara, Yasuhito, Takemori, Hiroshi, Okada, Minoru, Kosai, Azuma, Yamashita, Akihiro, Kobayashi, Tomohito, Fujita, Kaori, Itoh, Yumi, Nakamura, Masahiro, Fuchino, Hiroyuki, Kawahara, Nobuo, Fukui, Naoshi, Watanabe, Akira, Kimura, Tomoatsu, Tsumaki, Noriyuki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820810/
https://ncbi.nlm.nih.gov/pubmed/27009967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10959
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