Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis

OBJECTIVE: We identified significant expression of the matricellular protein, DEL1, in hypertrophic and mature cartilage during development. We hypothesized that this tissue-specific expression indicated a biological role for DEL1 in cartilage biology. METHODS: Del1 KO and WT mice had cartilage thic...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wang, Zhen, Tran, Misha C., Bhatia, Namrata J., Hsing, Alexander W., Chen, Carol, LaRussa, Marie F., Fattakhov, Ernst, Rashidi, Vania, Jang, Kyu Yun, Choo, Kevin J., Nie, Xingju, Mathy, Jonathan A., Longaker, Michael T., Dauskardt, Reinhold H., Helms, Jill A., Yang, George P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978450/
https://ncbi.nlm.nih.gov/pubmed/27505251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160684
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