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Conformational selectivity in cytochrome P450 redox partner interactions

The heme iron of cytochromes P450 must be reduced to bind and activate molecular oxygen for substrate oxidation. Reducing equivalents are derived from a redox partner, which requires the formation of a protein–protein complex. A subject of increasing discussion is the role that redox partner binding...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hollingsworth, Scott A., Batabyal, Dipanwita, Nguyen, Brian D., Poulos, Thomas L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978276/
https://ncbi.nlm.nih.gov/pubmed/27439869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606474113
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