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Conformational selectivity in cytochrome P450 redox partner interactions

The heme iron of cytochromes P450 must be reduced to bind and activate molecular oxygen for substrate oxidation. Reducing equivalents are derived from a redox partner, which requires the formation of a protein–protein complex. A subject of increasing discussion is the role that redox partner binding...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Hollingsworth, Scott A., Batabyal, Dipanwita, Nguyen, Brian D., Poulos, Thomas L.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978276/
https://ncbi.nlm.nih.gov/pubmed/27439869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606474113
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