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Effect of Redox Partner Binding on Cytochrome P450 Conformational Dynamics
Previous crystal structures of cytochrome P450cam complexed with its redox partner, putidaredoxin (Pdx), shows that P450cam adopts the open conformation. It has been hypothesized that the Pdx-induced shift toward the open state frees the essential Asp251 from salt bridges with Arg186 and Lys178 so t...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5640156/ https://ncbi.nlm.nih.gov/pubmed/28823160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b07656 |
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