Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis

AKI increases the risk of developing CKD, but the mechanisms linking AKI to CKD remain unclear. Because proximal tubule injury is the mainstay of AKI, we postulated that proximal tubule injury triggers features of CKD. We generated a novel mouse model to induce proximal tubule–specific adjustable in...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Takaori, Koji, Nakamura, Jin, Yamamoto, Shinya, Nakata, Hirosuke, Sato, Yuki, Takase, Masayuki, Nameta, Masaaki, Yamamoto, Tadashi, Economides, Aris N., Kohno, Kenji, Haga, Hironori, Sharma, Kumar, Yanagita, Motoko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2016
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978049/
https://ncbi.nlm.nih.gov/pubmed/26701981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015060647
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