Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis

AKI increases the risk of developing CKD, but the mechanisms linking AKI to CKD remain unclear. Because proximal tubule injury is the mainstay of AKI, we postulated that proximal tubule injury triggers features of CKD. We generated a novel mouse model to induce proximal tubule–specific adjustable in...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Takaori, Koji, Nakamura, Jin, Yamamoto, Shinya, Nakata, Hirosuke, Sato, Yuki, Takase, Masayuki, Nameta, Masaaki, Yamamoto, Tadashi, Economides, Aris N., Kohno, Kenji, Haga, Hironori, Sharma, Kumar, Yanagita, Motoko
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2016
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978049/
https://ncbi.nlm.nih.gov/pubmed/26701981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015060647
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