Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis

AKI increases the risk of developing CKD, but the mechanisms linking AKI to CKD remain unclear. Because proximal tubule injury is the mainstay of AKI, we postulated that proximal tubule injury triggers features of CKD. We generated a novel mouse model to induce proximal tubule–specific adjustable in...

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Veröffentlicht in:J Am Soc Nephrol
Hauptverfasser: Takaori, Koji, Nakamura, Jin, Yamamoto, Shinya, Nakata, Hirosuke, Sato, Yuki, Takase, Masayuki, Nameta, Masaaki, Yamamoto, Tadashi, Economides, Aris N., Kohno, Kenji, Haga, Hironori, Sharma, Kumar, Yanagita, Motoko
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2016
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978049/
https://ncbi.nlm.nih.gov/pubmed/26701981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015060647
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