Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis

AKI increases the risk of developing CKD, but the mechanisms linking AKI to CKD remain unclear. Because proximal tubule injury is the mainstay of AKI, we postulated that proximal tubule injury triggers features of CKD. We generated a novel mouse model to induce proximal tubule–specific adjustable in...

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Dettagli Bibliografici
Pubblicato in:J Am Soc Nephrol
Autori principali: Takaori, Koji, Nakamura, Jin, Yamamoto, Shinya, Nakata, Hirosuke, Sato, Yuki, Takase, Masayuki, Nameta, Masaaki, Yamamoto, Tadashi, Economides, Aris N., Kohno, Kenji, Haga, Hironori, Sharma, Kumar, Yanagita, Motoko
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2016
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978049/
https://ncbi.nlm.nih.gov/pubmed/26701981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015060647
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