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Hedgehog signaling inhibition by the small molecule Smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b

BACKGROUND: Hedgehog signaling is a stromal-mesenchymal pathway central to the development and homeostasis of both the prostate and the bone. Aberrant Hedgehog signaling activation has been associated with prostate cancer aggressiveness. We hypothesize that Hedgehog pathway is a candidate therapeuti...

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Publicat a:Prostate
Autors principals: Karlou, Maria, Tzelepi, Vassiliki, Maity, Sankar, Navone, Nora M., Yang, Jun, Hoang, Anh, Lu, Jing-Fang, Logothetis, Christopher J., Efstathiou, Eleni
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4977841/
https://ncbi.nlm.nih.gov/pubmed/22457212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.22517
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