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Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2

A series of lobelane and GZ-793A analogues that incorporate aromatic 4-hydroxy and 4-(2-fluoroethoxy) substituents were synthesized and evaluated for inhibition of [(3)H]dopamine (DA) uptake at the vesicular monoamine transporter-2 (VMAT2) and the dopamine transporter (DAT), and [(3)H]serotonin upta...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem Lett
Main Authors: Joolakanti, Shyam R., Nickell, Justin R., Janganati, Venumadhav, Zheng, Guangrong, Dwoskin, Linda P., Crooks, Peter A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4977194/
https://ncbi.nlm.nih.gov/pubmed/27080180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.03.119
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