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Notch-1 activates estrogen receptor-α-dependent transcription via IKKα in breast cancer cells
Approximately 80% of breast cancers express the estrogen receptor-α (ERα) and are treated with anti-estrogens. Resistance to these agents is a major cause of mortality. We have shown that estrogen inhibits Notch, whereas anti-estrogens or estrogen withdrawal activate Notch signaling. Combined inhibi...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4976641/ https://ncbi.nlm.nih.gov/pubmed/19838210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.323 |
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