Estrogen receptor β–dependent Notch1 activation protects vascular endothelium against tumor necrosis factor α (TNFα)-induced apoptosis

Unlike age-matched men, premenopausal women benefit from cardiovascular protection. Estrogens protect against apoptosis of endothelial cells (ECs), one of the hallmarks of endothelial dysfunction leading to cardiovascular disorders, but the underlying molecular mechanisms remain poorly understood. T...

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Vydáno v:J Biol Chem
Hlavní autoři: Fortini, Francesca, Vieceli Dalla Sega, Francesco, Caliceti, Cristiana, Aquila, Giorgio, Pannella, Micaela, Pannuti, Antonio, Miele, Lucio, Ferrari, Roberto, Rizzo, Paola
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672041/
https://ncbi.nlm.nih.gov/pubmed/28893903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.790121
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