Estrogen receptor β–dependent Notch1 activation protects vascular endothelium against tumor necrosis factor α (TNFα)-induced apoptosis

Unlike age-matched men, premenopausal women benefit from cardiovascular protection. Estrogens protect against apoptosis of endothelial cells (ECs), one of the hallmarks of endothelial dysfunction leading to cardiovascular disorders, but the underlying molecular mechanisms remain poorly understood. T...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Fortini, Francesca, Vieceli Dalla Sega, Francesco, Caliceti, Cristiana, Aquila, Giorgio, Pannella, Micaela, Pannuti, Antonio, Miele, Lucio, Ferrari, Roberto, Rizzo, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672041/
https://ncbi.nlm.nih.gov/pubmed/28893903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.790121
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