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Zbtb1 safeguards genome integrity and prevents p53-mediated apoptosis in proliferating lymphoid progenitors()
Expression of the transcription factor Zbtb1 is required for normal lymphoid development. We report here that Zbtb1 maintains genome integrity in immune progenitors without which cells undergo increased DNA damage and p53-mediated apoptosis during replication and differentiation. Increased DNA damag...
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| Published in: | J Immunol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4976014/ https://ncbi.nlm.nih.gov/pubmed/27402700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600013 |
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