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Environmental Stress Induces Trinucleotide Repeat Mutagenesis In Human Cells By Alt-Nonhomologous End Joining Repair
Multiple pathways modulate the dynamic mutability of trinucleotide repeats (TNRs), which are implicated in neurodegenerative disease and evolution. Recently, we reported that environmental stresses induce TNR mutagenesis via stress responses and rereplication, with more than 50% of mutants carrying...
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| Udgivet i: | J Mol Biol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4975952/ https://ncbi.nlm.nih.gov/pubmed/27318194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.06.004 |
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