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Environmental Stress Induces Trinucleotide Repeat Mutagenesis In Human Cells By Alt-Nonhomologous End Joining Repair

Multiple pathways modulate the dynamic mutability of trinucleotide repeats (TNRs), which are implicated in neurodegenerative disease and evolution. Recently, we reported that environmental stresses induce TNR mutagenesis via stress responses and rereplication, with more than 50% of mutants carrying...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Chatterjee, Nimrat, Lin, Yunfu, Yotnda, Patricia, Wilson, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975952/
https://ncbi.nlm.nih.gov/pubmed/27318194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.06.004
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