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An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway
Pro-apoptotic BAX is a cell fate regulator playing an important role in cellular homeostasis and pathological cell death. BAX is predominantly localized in the cytosol where it has a quiescent monomer conformation. Following a pro-apoptotic trigger, cytosolic BAX is activated and translocates to the...
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| Publicado no: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4975667/ https://ncbi.nlm.nih.gov/pubmed/27425408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.06.010 |
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