Combination of eribulin and Aurora A inhibitor MLN8237 prevents metastatic colonization and induces cytotoxic autophagy in breast cancer

Recent findings suggest that the inhibition of Aurora A (AURKA) kinase may offer a novel treatment strategy against metastatic cancers. In the current study, we determined the effects of AURKA inhibition by the small molecule inhibitor MLN8237 both as a monotherapy and in combination with the microt...

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Publicado no:Mol Cancer Ther
Main Authors: Kozyreva, Varvara K., Kiseleva, Anna A., Ice, Ryan J., Jones, Brandon C., Loskutov, Yuriy V., Matalkah, Fatimah, Smolkin, Matthew B., Marinak, Kristina, Livengood, Ryan H., Salkeni, Mohamad A., Wen, Sijin, Hazard, Hannah W., Layne, Ginger P., Walsh, Callee M., Cantrell, Pamela S., Kilby, Greg W., Mahavadi, Sricharan, Shah, Neal, Pugacheva, Elena N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975626/
https://ncbi.nlm.nih.gov/pubmed/27235164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0688
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