Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation

The high prevalence of KRAS mutations and importance of the RalGEF-Ral pathway downstream of activated K-Ras in pancreatic ductal adenocarcinoma (PDAC) emphasize the importance of identifying novel methods by which to therapeutically target these pathways. It was recently demonstrated that phosphory...

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Bibliografiska uppgifter
Huvudupphovsmän: Neel, Nicole F., Stratford, Jeran K., Shinde, Vaishali, Ecsedy, Jeffrey A., Martin, Timothy D., Der, Channing J., Yeh, Jen Jen
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910332/
https://ncbi.nlm.nih.gov/pubmed/24222664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-1232
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