Therapeutic activity of agonistic, human anti-CD40 monoclonal Abs requires selective FcγR-engagement

While engagement of the inhibitory Fcγ-Receptor (FcγR) IIB is an absolute requirement for in vivo antitumor activity of agonistic mouse anti-CD40 monoclonal antibodies (mAbs), a similar requirement for human mAbs has been disputed. By using a mouse model humanized for its FcγRs and CD40, we revealed...

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Detaylı Bibliyografya
Yayımlandı:Cancer Cell
Asıl Yazarlar: Dahan, Rony, Barnhart, Bryan C., Li, Fubin, Yamniuk, Aaron P., Korman, Alan, Ravetch, Jeffrey V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975533/
https://ncbi.nlm.nih.gov/pubmed/27265505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.05.001
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