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Antitumor activities of agonistic anti-TNFR antibodies require differential FcγRIIB coengagement in vivo
Agonistic anti-TNF receptor (TNFR) superfamily member antibodies are a class of promising antitumor therapies in active clinical investigation. An unexpected requirement for inhibitory Fcγ receptor FcγRIIB coengagement has recently been described for their in vivo antitumor activities. Although thes...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3845179/ https://ncbi.nlm.nih.gov/pubmed/24218606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319502110 |
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