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Antitumor activities of agonistic anti-TNFR antibodies require differential FcγRIIB coengagement in vivo

Agonistic anti-TNF receptor (TNFR) superfamily member antibodies are a class of promising antitumor therapies in active clinical investigation. An unexpected requirement for inhibitory Fcγ receptor FcγRIIB coengagement has recently been described for their in vivo antitumor activities. Although thes...

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Hlavní autoři: Li, Fubin, Ravetch, Jeffrey V.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845179/
https://ncbi.nlm.nih.gov/pubmed/24218606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319502110
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