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Inhibitory Fcγ receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies
CD40, a member of the TNF receptor (TNFR) superfamily, is expressed on antigen presenting cells (APCs) and is essential for immune activation. While agonistic CD40 antibodies have been developed for immunotherapy, their clinical efficacy has been limited. We have found that co-engagement of the Fc d...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3164589/ https://ncbi.nlm.nih.gov/pubmed/21852502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1206954 |
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