Extremely long range chromatin loops link topological domains to facilitate a diverse antibody repertoire

Early B cell development is characterized by large scale Igh locus contraction prior to V(D)J recombination to facilitate a highly diverse Ig repertoire. However, an understanding of the molecular architecture that mediates locus contraction remains unclear. We have combined high resolution chromoso...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Montefiori, Lindsey, Wuerffel, Robert, Roqueiro, Damian, Lajoie, Bryan, Guo, Changying, Gerasimova, Tatiana, De, Supriyo, Wood, William, Becker, Kevin G., Dekker, Job, Liang, Jie, Sen, Ranjan, Kenter, Amy L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975037/
https://ncbi.nlm.nih.gov/pubmed/26804913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.083
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