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Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene.

Transgenic mice were produced containing the adipocyte-specific regulatory region from the adipocyte P2 (aP2) gene linked to the simian virus 40 transforming genes. Most of the transgenic mice developed brown fat tumors (hibernomas) in their interscapular brown adipose tissue. Hibernoma formation wa...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Ross, S R, Choy, L, Graves, R A, Fox, N, Solevjeva, V, Klaus, S, Ricquier, D, Spiegelman, B M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49750/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1323843/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.16.7561
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