A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting

Live-cell imaging has revealed unexpected features of gene expression. Here using improved single-molecule RNA microscopy, we show that synthesis of HIV-1 RNA is achieved by groups of closely spaced polymerases, termed convoys, as opposed to single isolated enzymes. Convoys arise by a Mediator-depen...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Tantale, Katjana, Mueller, Florian, Kozulic-Pirher, Alja, Lesne, Annick, Victor, Jean-Marc, Robert, Marie-Cécile, Capozi, Serena, Chouaib, Racha, Bäcker, Volker, Mateos-Langerak, Julio, Darzacq, Xavier, Zimmer, Christophe, Basyuk, Eugenia, Bertrand, Edouard
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974459/
https://ncbi.nlm.nih.gov/pubmed/27461529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12248
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