Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting

Promoter-proximal pausing of RNA polymerase II is a key process regulating gene expression. In latent HIV-1 cells, it prevents viral transcription and is essential for latency maintenance, while in acutely infected cells the viral factor Tat releases paused polymerase to induce viral expression. Pau...

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Publicado no:Nat Commun
Main Authors: Tantale, Katjana, Garcia-Oliver, Encar, Robert, Marie-Cécile, L’Hostis, Adèle, Yang, Yueyuxiao, Tsanov, Nikolay, Topno, Rachel, Gostan, Thierry, Kozulic-Pirher, Alja, Basu-Shrivastava, Meenakshi, Mukherjee, Kamalika, Slaninova, Vera, Andrau, Jean-Christophe, Mueller, Florian, Basyuk, Eugenia, Radulescu, Ovidiu, Bertrand, Edouard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302722/
https://ncbi.nlm.nih.gov/pubmed/34301927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24462-5
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