How Glycosaminoglycans Promote Fibrillation of Salmon Calcitonin

Glycosaminoglycans (GAGs) bind all known amyloid plaques and help store protein hormones in (acidic) granular vesicles, but the molecular mechanisms underlying these important effects are unclear. Here we investigate GAG interactions with the peptide hormone salmon calcitonin (sCT). GAGs induce fast...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Malmos, Kirsten Gade, Bjerring, Morten, Jessen, Christian Moestrup, Nielsen, Erik Holm Toustrup, Poulsen, Ebbe T., Christiansen, Gunna, Vosegaard, Thomas, Skrydstrup, Troels, Enghild, Jan J., Pedersen, Jan Skov, Otzen, Daniel E.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974396/
https://ncbi.nlm.nih.gov/pubmed/27281819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.715466
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