How Glycosaminoglycans Promote Fibrillation of Salmon Calcitonin

Glycosaminoglycans (GAGs) bind all known amyloid plaques and help store protein hormones in (acidic) granular vesicles, but the molecular mechanisms underlying these important effects are unclear. Here we investigate GAG interactions with the peptide hormone salmon calcitonin (sCT). GAGs induce fast...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Malmos, Kirsten Gade, Bjerring, Morten, Jessen, Christian Moestrup, Nielsen, Erik Holm Toustrup, Poulsen, Ebbe T., Christiansen, Gunna, Vosegaard, Thomas, Skrydstrup, Troels, Enghild, Jan J., Pedersen, Jan Skov, Otzen, Daniel E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974396/
https://ncbi.nlm.nih.gov/pubmed/27281819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.715466
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