How Glycosaminoglycans Promote Fibrillation of Salmon Calcitonin

Glycosaminoglycans (GAGs) bind all known amyloid plaques and help store protein hormones in (acidic) granular vesicles, but the molecular mechanisms underlying these important effects are unclear. Here we investigate GAG interactions with the peptide hormone salmon calcitonin (sCT). GAGs induce fast...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Malmos, Kirsten Gade, Bjerring, Morten, Jessen, Christian Moestrup, Nielsen, Erik Holm Toustrup, Poulsen, Ebbe T., Christiansen, Gunna, Vosegaard, Thomas, Skrydstrup, Troels, Enghild, Jan J., Pedersen, Jan Skov, Otzen, Daniel E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2016
Предметы:
Protein Structure and Folding
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974396/
https://ncbi.nlm.nih.gov/pubmed/27281819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.715466
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