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CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress

Our previous study suggested that ceramide synthase 6 (CerS6), an enzyme in sphingolipid biosynthesis, is regulated by p53: CerS6 was elevated in several cell lines in response to transient expression of p53 or in response to folate stress, which is known to activate p53. It was not clear, however,...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Fekry, Baharan, Jeffries, Kristen A., Esmaeilniakooshkghazi, Amin, Ogretmen, Besim, Krupenko, Sergey A., Krupenko, Natalia I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974374/
https://ncbi.nlm.nih.gov/pubmed/27302066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.716902
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