BLVRB redox mutation defines heme degradation in a metabolic pathway of enhanced thrombopoiesis in humans

Human blood cell counts are tightly maintained within narrow physiologic ranges, largely controlled by cytokine-integrated signaling and transcriptional circuits that regulate multilineage hematopoietic specification. Known genetic loci influencing blood cell production account for <10% of platel...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Wu, Song, Li, Zongdong, Gnatenko, Dmitri V., Zhang, Beibei, Zhao, Lu, Malone, Lisa E., Markova, Nedialka, Mantle, Timothy J., Nesbitt, Natasha M., Bahou, Wadie F.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2016
Assuntos:
Platelets and Thrombopoiesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974201/
https://ncbi.nlm.nih.gov/pubmed/27207795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-02-696997
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