Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer’s disease

Conformational phosphorylation and cleavage events drive the tau protein from a soluble, monomeric state to a relatively insoluble, polymeric state that precipitates the formation of neurofibrillary tangles (NFTs) in projection neurons in Alzheimer’s disease (AD), including the magnocellular perikar...

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Publicado en:Neurobiol Aging
Autores principales: Tiernan, Chelsea T., Ginsberg, Stephen D., Guillozet-Bongaarts, Angela L., Ward, Sarah M., He, Bin, Kanaan, Nicholas M., Mufson, Elliott J., Binder, Lester I., Counts, Scott E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973891/
https://ncbi.nlm.nih.gov/pubmed/27143424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2016.02.031
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