Interleukin-11 Receptor Is a Candidate Target for Ligand-Directed Therapy in Lung Cancer: Analysis of Clinical Samples and BMTP-11 Preclinical Activity

We previously isolated an IL-11–mimic motif (CGRRAGGSC) that binds to IL-11 receptor (IL-11R) in vitro and accumulates in IL-11R–expressing tumors in vivo. This synthetic peptide ligand was used as a tumor-targeting moiety in the rational design of BMTP-11, which is a drug candidate in clinical tria...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Am J Pathol
Asıl Yazarlar: Cardó-Vila, Marina, Marchiò, Serena, Sato, Masanori, Staquicini, Fernanda I., Smith, Tracey L., Bronk, Julianna K., Yin, Guosheng, Zurita, Amado J., Sun, Menghong, Behrens, Carmen, Sidman, Richard L., Lee, J. Jack, Hong, Waun K., Wistuba, Ignacio I., Arap, Wadih, Pasqualini, Renata
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Investigative Pathology 2016
Konular:
Regular Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973658/
https://ncbi.nlm.nih.gov/pubmed/27317903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.04.013
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller