Interleukin-11 Receptor Is a Candidate Target for Ligand-Directed Therapy in Lung Cancer: Analysis of Clinical Samples and BMTP-11 Preclinical Activity

We previously isolated an IL-11–mimic motif (CGRRAGGSC) that binds to IL-11 receptor (IL-11R) in vitro and accumulates in IL-11R–expressing tumors in vivo. This synthetic peptide ligand was used as a tumor-targeting moiety in the rational design of BMTP-11, which is a drug candidate in clinical tria...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Am J Pathol
Autori principali: Cardó-Vila, Marina, Marchiò, Serena, Sato, Masanori, Staquicini, Fernanda I., Smith, Tracey L., Bronk, Julianna K., Yin, Guosheng, Zurita, Amado J., Sun, Menghong, Behrens, Carmen, Sidman, Richard L., Lee, J. Jack, Hong, Waun K., Wistuba, Ignacio I., Arap, Wadih, Pasqualini, Renata
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2016
Soggetti:
Regular Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973658/
https://ncbi.nlm.nih.gov/pubmed/27317903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.04.013
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi