Self-targeting of TNF-releasing cancer cells in preclinical models of primary and metastatic tumors

Circulating cancer cells can putatively colonize distant organs to form metastases or to reinfiltrate primary tumors themselves through a process termed “tumor self-seeding.” Here we exploit this biological attribute to deliver tumor necrosis factor alpha (TNF), a potent antitumor cytokine, directly...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dondossola, Eleonora, Dobroff, Andrey S., Marchiò, Serena, Cardó-Vila, Marina, Hosoya, Hitomi, Libutti, Steven K., Corti, Angelo, Sidman, Richard L., Arap, Wadih, Pasqualini, Renata
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776485/
https://ncbi.nlm.nih.gov/pubmed/26858439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525697113
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