Insights Into the Allosteric Inhibition of Ubc9, the SUMO E2 Enzyme

Conjugation of the small ubiquitin-like modifier (SUMO) to protein substrates is an important disease-associated posttranslational modification, though few inhibitors of this process are known. Here, we report the discovery of an allosteric small molecule binding site on Ubc9, the sole SUMO E2 enzym...

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Foilsithe in:Angew Chem Int Ed Engl
Main Authors: Hewitt, William M., Lountos, George T., Zlotkowski, Katherine, Dahlhauser, Samuel D., Saunders, Lindsey B., Needle, Danielle, Tropea, Joseph E., Zhan, Chendi, Wei, Guanghong, Ma, Buyong, Nussinov, Ruth, Waugh, David S., Schneekloth, John S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973392/
https://ncbi.nlm.nih.gov/pubmed/27038327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201511351
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