Insights Into the Allosteric Inhibition of Ubc9, the SUMO E2 Enzyme

Conjugation of the small ubiquitin-like modifier (SUMO) to protein substrates is an important disease-associated posttranslational modification, though few inhibitors of this process are known. Here, we report the discovery of an allosteric small molecule binding site on Ubc9, the sole SUMO E2 enzym...

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Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Hewitt, William M., Lountos, George T., Zlotkowski, Katherine, Dahlhauser, Samuel D., Saunders, Lindsey B., Needle, Danielle, Tropea, Joseph E., Zhan, Chendi, Wei, Guanghong, Ma, Buyong, Nussinov, Ruth, Waugh, David S., Schneekloth, John S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973392/
https://ncbi.nlm.nih.gov/pubmed/27038327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201511351
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