A Small-Molecule Microarray Approach for the Identification of E2 Enzyme Inhibitors in Ubiquitin-Like Conjugation Pathways

E2 enzymes in ubiquitin–like conjugation pathways are important, highly challenging pharmacological targets, and despite significant efforts, few noncovalent modulators have been discovered. Small–molecule microarray (SMM)–based screening was employed to identify an inhibitor of the “undruggable” sm...

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Detalhes bibliográficos
Publicado no:SLAS Discov
Main Authors: Zlotkowski, Katherine, Hewitt, William M., Sinniah, Ranu S., Tropea, Joseph E., Needle, Danielle, Lountos, George T., Barchi, Joseph J., Waugh, David S., Schneekloth, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344942/
https://ncbi.nlm.nih.gov/pubmed/28346086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555216683937
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