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Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase
High-frequency point mutations of genes encoding histones have been identified recently as novel drivers in a number of tumors. Specifically, the H3K36M/I mutations were shown to be oncogenic in chondroblastomas and undifferentiated sarcomas by inhibiting H3K36 methyltransferases, including SETD2. H...
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| Vydáno v: | Genes Dev |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4973290/ https://ncbi.nlm.nih.gov/pubmed/27474439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.284323.116 |
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