Molecular basis for histone N-terminal methylation by NRMT1

NRMT1 is an N-terminal methyltransferase that methylates histone CENP-A as well as nonhistone substrates. Here, we report the crystal structure of human NRMT1 bound to CENP-A peptide at 1.3 Å. NRMT1 adopts a core methyltransferase fold that resembles DOT1L and PRMT but not SET domain family histone...

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Bibliographic Details
Published in:Genes Dev
Main Authors: Wu, Ruoxi, Yue, Yuan, Zheng, Xiangdong, Li, Haitao
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2015
Subjects:
Research Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691888/
https://ncbi.nlm.nih.gov/pubmed/26543159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.270926.115
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