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Molecular basis for histone N-terminal methylation by NRMT1
NRMT1 is an N-terminal methyltransferase that methylates histone CENP-A as well as nonhistone substrates. Here, we report the crystal structure of human NRMT1 bound to CENP-A peptide at 1.3 Å. NRMT1 adopts a core methyltransferase fold that resembles DOT1L and PRMT but not SET domain family histone...
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| Publicado no: | Genes Dev |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4691888/ https://ncbi.nlm.nih.gov/pubmed/26543159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.270926.115 |
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