Cancer cell-derived 12(S)-HETE signals via 12-HETE receptor, RHO, ROCK and MLC2 to induce lymph endothelial barrier breaching

BACKGROUND: The arachidonic acid metabolite 12(S)-HETE is suspected to enhance metastatic spread by inducing cancer cell- and lymph endothelial cell (LEC) motility. However, the molecular mechanisms leading to 12(S)-HETE-triggered cell migration are still elusive. METHODS: To delineate the signallin...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Nguyen, Chi Huu, Stadler, Serena, Brenner, Stefan, Huttary, Nicole, Krieger, Sigurd, Jäger, Walter, Dolznig, Helmut, Krupitza, Georg
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973159/
https://ncbi.nlm.nih.gov/pubmed/27362730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.201
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