NF-κB contributes to MMP1 expression in breast cancer spheroids causing paracrine PAR1 activation and disintegrations in the lymph endothelial barrier in vitro

RELA, RELB, CREL, NFKB1 and NFKB2, and the upstream regulators NEMO and NIK were knocked-down in lymph endothelial cells (LECs) and in MDA-MB231 breast cancer spheroids to study the contribution of NF-κB in vascular barrier breaching. Suppression of RELA, NFKB1 and NEMO inhibited “circular chemo-rep...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Nguyen, Chi Huu, Senfter, Daniel, Basilio, Jose, Holzner, Silvio, Stadler, Serena, Krieger, Sigurd, Huttary, Nicole, Milovanovic, Daniela, Viola, Katharina, Simonitsch-Klupp, Ingrid, Jäger, Walter, de Martin, Rainer, Krupitza, Georg
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770771/
https://ncbi.nlm.nih.gov/pubmed/26513020
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