Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca(2+) signalling

Retraction of mesenchymal stromal cells supports the invasion of colorectal cancer cells (CRC) into the adjacent compartment. CRC-secreted 12(S)-HETE enhances the retraction of cancer-associated fibroblasts (CAFs) and therefore, 12(S)-HETE may enforce invasivity of CRC. Understanding the mechanisms...

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Publicat a:Cell Mol Life Sci
Autors principals: Stadler, Serena, Nguyen, Chi Huu, Schachner, Helga, Milovanovic, Daniela, Holzner, Silvio, Brenner, Stefan, Eichsteininger, Julia, Stadler, Mira, Senfter, Daniel, Krenn, Liselotte, Schmidt, Wolfgang M., Huttary, Nicole, Krieger, Sigurd, Koperek, Oskar, Bago-Horvath, Zsuzsanna, Brendel, Konstantin Alexander, Marian, Brigitte, de Wever, Oliver, Mader, Robert M., Giessrigl, Benedikt, Jäger, Walter, Dolznig, Helmut, Krupitza, Georg
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5390003/
https://ncbi.nlm.nih.gov/pubmed/28013338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-016-2441-5
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