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Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells

BACKGROUND: The role of anaplerotic nutrient entry into the Krebs cycle via pyruvate carboxylase has been the subject of increased scrutiny and in particular whether this is dysregulated in cancer. Here, we use a tracer-based NMR analysis involving high-resolution (1)H-(13)C-HSQC spectra to assess s...

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Detalhes bibliográficos
Publicado no:Cancer Metab
Main Authors: Reed, Michelle A. C., Ludwig, Christian, Bunce, Christopher M., Khanim, Farhat L., Günther, Ulrich L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972992/
https://ncbi.nlm.nih.gov/pubmed/27493727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-016-0155-7
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