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Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells
BACKGROUND: The role of anaplerotic nutrient entry into the Krebs cycle via pyruvate carboxylase has been the subject of increased scrutiny and in particular whether this is dysregulated in cancer. Here, we use a tracer-based NMR analysis involving high-resolution (1)H-(13)C-HSQC spectra to assess s...
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| Published in: | Cancer Metab |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
BioMed Central
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4972992/ https://ncbi.nlm.nih.gov/pubmed/27493727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-016-0155-7 |
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